Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80487
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
1420±91 nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80487
Synonyms:
1-(cyclohexoxy)-3-(2-ethyl-3-methyl-benzimidazol-3-ium-1-yl)propan-2-ol;iodide | 1-cyclohexyloxy-3-(2-ethyl-3-methyl-1-benzimidazol-3-iumyl)-2-propanol;iodide | 1-cyclohexyloxy-3-(2-ethyl-3-methyl-benzimidazol-3-ium-1-yl)propan-2-ol;iodide | 1-cyclohexyloxy-3-(2-ethyl-3-methylbenzimidazol-3-ium-1-yl)propan-2-ol;iodide | MLS000712815 | SMR000282582 | cid_2885201
Type:
Small organic molecule
Emp. Form.:
C19H29N2O2
Mol. Mass.:
317.4452
SMILES:
CCc1n(CC(O)COC2CCCCC2)c2ccccc2[n+]1C
Structure:
