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Target
DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80361
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1350±n/a nM
Comments
extracted
Citation
 PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] 
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
  
Inhibitor
Name:
BDBM80361
Synonyms:
5-(diethylamino)-2-hydroximino-valeric acid ethyl ester;iodomethane | 5-(diethylamino)-2-hydroxyiminopentanoic acid ethyl ester;iodomethane | MLS000047831 | SMR000033832 | cid_6411257 | ethyl (2Z)-5-(diethylamino)-2-(hydroxyimino)pentanoate | ethyl 5-(diethylamino)-2-hydroxyimino-pentanoate;iodanylmethane | ethyl 5-(diethylamino)-2-hydroxyiminopentanoate;iodomethane
Type:
Small organic molecule
Emp. Form.:
C11H22N2O3
Mol. Mass.:
230.304
SMILES:
CCOC(=O)C(CCCN(CC)CC)N=O
Structure:
Search PDB for entries with ligand similarity: