Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80372
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1760±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80372
Synonyms:
3,4-dimethyl-1-(1H-tetrazol-5-yl)pyrano[2,3-c]pyrazol-6(1H)-one | 3,4-dimethyl-1-(2H-1,2,3,4-tetrazol-5-yl)pyrano[2,3-c]pyrazol-6-one | 3,4-dimethyl-1-(2H-tetrazol-5-yl)-6-pyrano[2,3-c]pyrazolone | 3,4-dimethyl-1-(2H-tetrazol-5-yl)pyrano[2,3-c]pyrazol-6-one | MLS000049634 | SMR000076214 | cid_978252
Type:
Small organic molecule
Emp. Form.:
C9H8N6O2
Mol. Mass.:
232.1988
SMILES:
Cc1nn(-c2nnn[nH]2)c2oc(=O)cc(C)c12
Structure:
