Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80458
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1140±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80458
Synonyms:
(1E,2E)-3-(2-nitrophenyl)acrylaldehyde (4,6-dipiperidin-1-yl-1,3,5-triazin-2-yl)hydrazone | (4,6-dipiperidino-s-triazin-2-yl)-[[(E)-3-(2-nitrophenyl)prop-2-enylidene]amino]amine | MLS000723636 | N-[[(E)-3-(2-nitrophenyl)prop-2-enylidene]amino]-4,6-bis(1-piperidinyl)-1,3,5-triazin-2-amine | N-[[(E)-3-(2-nitrophenyl)prop-2-enylidene]amino]-4,6-di(piperidin-1-yl)-1,3,5-triazin-2-amine | SMR000305231 | cid_16189284
Type:
Small organic molecule
Emp. Form.:
C22H28N8O2
Mol. Mass.:
436.5101
SMILES:
[O-][N+](=O)c1ccccc1CC=CN=Nc1nc(nc(n1)N1CCCCC1)N1CCCCC1 |w:13.14,11.12|
Structure:
