Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80535
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1610±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80535
Synonyms:
2-[4-[(Z)-2-cyano-3-keto-3-(3-phenylpropylamino)prop-1-enyl]-2-methoxy-phenoxy]acetic acid | 2-[4-[(Z)-2-cyano-3-oxidanylidene-3-(3-phenylpropylamino)prop-1-enyl]-2-methoxy-phenoxy]ethanoic acid | 2-[4-[(Z)-2-cyano-3-oxo-3-(3-phenylpropylamino)prop-1-enyl]-2-methoxyphenoxy]acetic acid | MLS001183995 | SMR000502923 | cid_7334009
Type:
Small organic molecule
Emp. Form.:
C22H22N2O5
Mol. Mass.:
394.4205
SMILES:
COc1cc(\C=C(\C#N)C(=O)NCCCc2ccccc2)ccc1OCC(O)=O
Structure:
