Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCyclin-dependent kinase 2
LigandBDBM81435
Substrate/Competitorn/a
Meas. Tech.In Vitro Kinase Assay
Ki 47±16 nM
Citation Wang, SGriffiths, GMidgley, CABarnett, ALCooper, MGrabarek, JIngram, LJackson, WKontopidis, GMcClue, SJMcInnes, CMcLachlan, JMeades, CMezna, MStuart, IThomas, MPZheleva, DILane, DPJackson, RCGlover, DMBlake, DGFischer, PM Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents. Chem Biol17:1111-21 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 2
Name:Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM81435
NameBDBM81435
Synonyms:CDK Inhibitor, 8
TypeSmall organic molecule
Emp. Form.C16H18N6O2S2
Mol. Mass.390.483
SMILESCCNS(=O)(=O)c1cccc(Nc2nccc(n2)-c2sc(N)nc2C)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a