Reaction Details Report a problem with these data
Target
Histamine H1 receptor
Ligand
BDBM50062261
Substrate
n/a
Ki
1.3±n/a nM
Comments
PDSP_1912
Citation
 Tran, VT; Chang, RS; Snyder, SH Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine. Proc Natl Acad Sci U S A 75:6290-4 (1978) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1_RAT | Hrh1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55716.35
Organism:
RAT
Description:
HISTAMINE H1 HRH1 RAT::P31390
Residue:
486
Sequence:
MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
  
Inhibitor
Name:
BDBM50062261
Synonyms:
CHEMBL829 | Dimethyl-(2-methyl-3-phenothiazin-10-yl-propyl)-amine | Methylpromazine | N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine | TRIMEPRAZINE | Temaril
Type:
Small organic molecule
Emp. Form.:
C18H22N2S
Mol. Mass.:
298.446
SMILES:
CC(CN(C)C)CN1c2ccccc2Sc2ccccc12
Structure:
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