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TargetSerotonin (5-HT) receptor
LigandBDBM50007871
Substrate/Competitorn/a
Ki 2.8±n/a nM
CommentsPDSP_1919
Citation Dumuis, AGozlan, HSebben, MAnsanay, HRizzi, CATurconi, MMonferini, EGiraldo, ESchiantarelli, PLadinsky, H Characterization of a novel 5-HT4 receptor antagonist of the azabicycloalkyl benzimidazolone class: DAU 6285. Naunyn Schmiedebergs Arch Pharmacol345:264-9 (1992) [PubMed]
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Serotonin (5-HT) receptor
Name:Serotonin (5-HT) receptor
Synonyms:5-HT3 | 5-hydroxytryptamine receptor 3A | Zacopride site-R
Type:Enzyme Catalytic Domain
Mol. Mass.:55428.70
Organism:RAT
Description:5-HT3 HTR3A RAT::P35563
Residue:483
Sequence:
MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDW
RKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSI
WVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTF
TSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFY
VVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTL
PATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLL
CLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAV
RGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW
HYS
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BDBM50007871
NameBDBM50007871
Synonyms:CHEMBL8197 | ICS 205-930 | TROPISETRON
TypeSmall organic molecule
Emp. Form.C17H20N2O2
Mol. Mass.284.3529
SMILESCN1C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12 |THB:9:7:1:3.4|
Structure
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n/a
NameBDBM50007871
Synonyms:CHEMBL8197 | ICS 205-930 | TROPISETRON
TypeSmall organic molecule
Emp. Form.C17H20N2O2
Mol. Mass.284.3529
SMILESCN1C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12 |THB:9:7:1:3.4|
Structure
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