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Reaction Details
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TargetBis(5'adenosyl)-triphosphatase
LigandBDBM81587
Substrate/Competitorn/a
Meas. Tech.Enzyme Inhibition Assay
Ki 900±0.0 nM
Citation Varnum, JMBaraniak, JKaczmarek, RStec, WJBrenner, C Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement. BMC Chem Biol1:3 (2001) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bis(5'adenosyl)-triphosphatase
Name:Bis(5'adenosyl)-triphosphatase
Synonyms:AP3A hydrolase | AP3Aase | Diadenosine 5',5'''-P1,P3-triphosphate hydrolase | Dinucleosidetriphosphatase | Fragile histidine triad protein
Type:Protein
Mol. Mass.:16861.00
Organism:Homo sapiens (Human)
Description:P49789
Residue:147
Sequence:
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQ
TTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKH
DKEDFPASWRSEEEMAAEAAALRVYFQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM81587
NameBDBM81587
Synonyms:AppppA analog, 14 (X=O)
TypeSmall organic molecule
Emp. Form.C25H32N10O22P4
Mol. Mass.948.4737
SMILESNc1ncnc2n(cnc12)C1O[C@H](COP([O-])(=O)OCC(COP([O-])([O-])=O)(COP([O-])([O-])=O)COP([O-])(=O)OCC2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r|
Structure
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