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TargetTubulin
LigandBDBM81751
Substrate/Competitorn/a
Meas. Tech.In Vitro Activity Assay
IC50 6.8e+4± 6e+3 nM
Citation Morgan, REAhn, SNzimiro, SFotie, JPhelps, MACotrill, JYakovich, AJSackett, DLDalton, JTWerbovetz, KA Inhibitors of tubulin assembly identified through screening a compound library. Chem Biol Drug Des72:513-24 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tubulin
Name:Tubulin
Synonyms:Alpha-tubulin
Type:Protein
Mol. Mass.:49756.63
Organism:Leishmania tarentolae (Sauroleishmania tarentolae)
Description:Q1A5Y2
Residue:451
Sequence:
MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGK
HVPRCLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALD
RIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTA
VVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTA
SLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVSDITNSVFEPAG
MLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPP
TVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGAESADDMGEEDVEEY
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BDBM81751
NameBDBM81751
Synonyms:Chembridge No 9041709, Class 2, 11
TypeSmall organic molecule
Emp. Form.C21H18N4O2
Mol. Mass.358.3932
SMILESO=C(N1CCN(CC1)c1oc(nc1C#N)-c1ccccc1)c1ccccc1
Structure
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n/a