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Target
Tubulin alpha chain
Ligand
BDBM81752
Substrate
n/a
Meas. Tech.
In Vitro Activity Assay
IC50
6.6e+4± 3e+3 nM
Citation
 Morgan, RE; Ahn, S; Nzimiro, S; Fotie, J; Phelps, MA; Cotrill, J; Yakovich, AJ; Sackett, DL; Dalton, JT; Werbovetz, KA Inhibitors of tubulin assembly identified through screening a compound library. Chem Biol Drug Des 72:513-24 (2008) [PubMed]  Article 
Target
Name:
Tubulin alpha chain
Synonyms:
Alpha-tubulin | Tubulin
Type:
Protein
Mol. Mass.:
49756.63
Organism:
Leishmania tarentolae (Sauroleishmania tarentolae)
Description:
Q1A5Y2
Residue:
451
Sequence:
MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRCLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVSDITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDMGEEDVEEY
  
Inhibitor
Name:
BDBM81752
Synonyms:
Chembridge No 9035650, Class 2, 12
Type:
Small organic molecule
Emp. Form.:
C22H20N4O3
Mol. Mass.:
388.4192
SMILES:
COc1ccc(cc1)C(=O)N1CCN(CC1)c1oc(nc1C#N)-c1ccccc1
Structure:
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