Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTubulin
LigandBDBM81757
Substrate/Competitorn/a
Meas. Tech.In Vitro Activity Assay
IC50 1.07e+5± 1.2e+4 nM
Citation Morgan, REAhn, SNzimiro, SFotie, JPhelps, MACotrill, JYakovich, AJSackett, DLDalton, JTWerbovetz, KA Inhibitors of tubulin assembly identified through screening a compound library. Chem Biol Drug Des72:513-24 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tubulin
Name:Tubulin
Synonyms:Alpha-tubulin
Type:Protein
Mol. Mass.:49756.63
Organism:Leishmania tarentolae (Sauroleishmania tarentolae)
Description:Q1A5Y2
Residue:451
Sequence:
MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGK
HVPRCLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALD
RIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTA
VVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTA
SLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVSDITNSVFEPAG
MLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPP
TVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGAESADDMGEEDVEEY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM81757
NameBDBM81757
Synonyms:Chembridge No 9049411, Class 4, 15
TypeSmall organic molecule
Emp. Form.C13H15ClN2O3S2
Mol. Mass.346.853
SMILESCOc1cc(NC(=O)CSC2=NCCS2)c(OC)cc1Cl |t:10|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a