Reaction Details Report a problem with these data
Target
Tubulin alpha chain
Ligand
BDBM81757
Substrate
n/a
Meas. Tech.
In Vitro Activity Assay
IC50
1.07e+5± 1.2e+4 nM
Citation
 Morgan, RE; Ahn, S; Nzimiro, S; Fotie, J; Phelps, MA; Cotrill, J; Yakovich, AJ; Sackett, DL; Dalton, JT; Werbovetz, KA Inhibitors of tubulin assembly identified through screening a compound library. Chem Biol Drug Des 72:513-24 (2008) [PubMed]  Article 
Target
Name:
Tubulin alpha chain
Synonyms:
Alpha-tubulin | Tubulin
Type:
Protein
Mol. Mass.:
49756.63
Organism:
Leishmania tarentolae (Sauroleishmania tarentolae)
Description:
Q1A5Y2
Residue:
451
Sequence:
MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGKHVPRCLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALDRIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVSDITNSVFEPAGMLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADDMGEEDVEEY
  
Inhibitor
Name:
BDBM81757
Synonyms:
Chembridge No 9049411, Class 4, 15
Type:
Small organic molecule
Emp. Form.:
C13H15ClN2O3S2
Mol. Mass.:
346.853
SMILES:
COc1cc(NC(=O)CSC2=NCCS2)c(OC)cc1Cl |t:10|
Structure:
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