Reaction Details Report a problem with these data
Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50002477
Substrate
n/a
Ki
25±n/a nM
Comments
PDSP_2195
Citation
 Lin, CW; Shiosaki, K; Miller, TR; Witte, DG; Bianchi, BR; Wolfram, CA; Kopecka, H; Craig, R; Wagenaar, F; Nadzan, AM Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol Pharmacol 39:346-51 (1991) [PubMed] 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCKBR | Cholecystokinin A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48683.10
Organism:
GUINEA PIG
Description:
Cholecystokinin A CCKBR GUINEA PIG::H0VZC5
Residue:
450
Sequence:
MELLKLNRSLQGPGPGPGAPLCRPAGPLLNSSGAGNVSCETPRIRGAGTRVKSMAILFNVTSLLSCWNKYRIIKVLGLSRRLRTVTKAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTAVQPVGPRVLQCVHRWPNARVRQTWSVLLLLLLFFVPGVVMAVAYGLISRELYLGLRFDGDADSESQSRVRGPGGLSGSAPGPAHQNGRCRPESGLSGEDSDGCYVQLPRSRPALELSALAASTPAPGPGPRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPEEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50002477
Synonyms:
(S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-4-methylsulfanyl-butyrylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid | 3-{1-[1-butyl oxycarbonylamino-2-(1H-3-indolyl)ethylcarboxamido]-3-methylsulfanylpropylcarboxamido}-3-(1-carbamoyl-2-phenylethylcarbamoyl)propanoic acid | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-4-methylsulfanyl-butyrylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Boc-CCK-4 | CHEMBL64605
Type:
Small organic molecule
Emp. Form.:
C34H44N6O8S
Mol. Mass.:
696.814
SMILES:
CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Structure:
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