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Target
Leucyl-cystinyl aminopeptidase
Ligand
BDBM271292
Substrate
n/a
Meas. Tech.
Inhibition of IRAP Assay
IC50
1.70±n/a nM
Citation
 Kawaguchi, K; Ishihata, A; Inagaki, Y; Tsuchiya, K; Hanadate, T; Kanai, A; Kaizawa, H; Kazami, J; Morikawa, H; Hiramoto, M; Enjo, K; Takamatsu, H Pyridine derivative US Patent  US10059720 Publication Date 8/28/2018 
Target
Name:
Leucyl-cystinyl aminopeptidase
Synonyms:
Cystinyl aminopeptidase | GP160 | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | Irap | LCAP_RAT | Leucyl-cystinyl aminopeptidase | Lnpep | Otase | Oxytocinase | P-LAP | Placental leucine aminopeptidase | Vesicle protein of 165 kDa | Vp165
Type:
PROTEIN
Mol. Mass.:
117179.39
Organism:
Rattus norvegicus
Description:
ChEMBL_98523
Residue:
1025
Sequence:
METFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMDEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGTCSVPSARTLVICVFVIVVAVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPIATNGKVFPWAQIRLPTAIIPQRYELSLHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISSVTFMSAVSSQEKQVEILEYPYHEQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAARSAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQDEFSESVKMSTYLVAFIVGEMRNLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKTLDVKKMMKTWTLQKGFPLVTVQRKGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVTDGRNYSEYRSVSLLDKKSDVINLTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNPYVLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLEKLGHMDLSSRLVTRVHKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMATKLFDGWMASNGTQSLPTDVMTTVFKVGARTEKGWLFLFSMYSSMGSEAEKDKILEALASSADAHKLYWLMKSSLDGDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQEFFENQSEATLQLRCVQEAFEVIELNIQWMARNLKTLTLWL
  
Inhibitor
Name:
BDBM271292
Synonyms:
US10059720, Example 107 | US10975091, Example 107
Type:
Small organic molecule
Emp. Form.:
C21H32N2O4S
Mol. Mass.:
408.555
SMILES:
C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CSC2CCC2)C(O)=O)c1 |r,wU:14.14,16.17,1.0,wD:4.7,14.15,(8.28,4.62,;6.94,3.85,;6.94,2.31,;5.61,1.54,;4.28,2.31,;4.28,3.85,;5.61,4.62,;2.94,1.54,;2.94,,;4.28,-.77,;4.28,-2.31,;2.94,-3.08,;1.61,-2.31,;.28,-3.08,;-1.06,-2.31,;-.29,-.98,;-2.39,-3.08,;-2.39,-4.62,;-3.72,-2.31,;-5.06,-3.08,;-6.39,-2.31,;-6.79,-.82,;-8.28,-1.22,;-7.88,-2.71,;-1.83,-.98,;-3.32,-1.37,;-1.06,.36,;1.61,-.77,)|
Structure:
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