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Target
Leucyl-cystinyl aminopeptidase
Ligand
BDBM271309
Substrate
n/a
Meas. Tech.
Inhibition of Human P-LAP (hP-LAP) Assay
IC50
2.90±n/a nM
Citation
 Kawaguchi, K; Ishihata, A; Inagaki, Y; Tsuchiya, K; Hanadate, T; Kanai, A; Kaizawa, H; Kazami, J; Morikawa, H; Hiramoto, M; Enjo, K; Takamatsu, H Pyridine derivative US Patent  US10059720 Publication Date 8/28/2018 
Target
Name:
Leucyl-cystinyl aminopeptidase
Synonyms:
Aminopeptidase | Aminopeptidase (P-LAP) | Cystinyl aminopeptidase | IRAP | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | LCAP_HUMAN | LNPEP | Leucyl-cystinyl aminopeptidase, pregnancy serum form | OTASE | Oxytocinase | P-LAP | Placental leucine aminopeptidase
Type:
PROTEIN
Mol. Mass.:
117334.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1473494
Residue:
1025
Sequence:
MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL
  
Inhibitor
Name:
BDBM271309
Synonyms:
US10059720, Example 124 | US10975091, Example 124
Type:
Small organic molecule
Emp. Form.:
C21H34N2O4
Mol. Mass.:
378.5057
SMILES:
C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)(C)C)C(O)=O)c1 |r,wU:14.14,16.17,1.0,wD:4.7,14.15,(7.34,4.62,;6,3.85,;6,2.31,;4.67,1.54,;3.33,2.31,;3.33,3.85,;4.67,4.62,;2,1.54,;2,,;3.33,-.77,;3.33,-2.31,;2,-3.08,;.67,-2.31,;-.67,-3.08,;-2,-2.31,;-1.23,-.98,;-3.33,-3.08,;-3.33,-4.62,;-4.67,-2.31,;-6,-3.08,;-7.34,-3.85,;-6.77,-1.75,;-5.23,-4.41,;-2.77,-.98,;-2,.36,;-4.26,-1.37,;.67,-.77,)|
Structure:
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