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Target
Leucyl-cystinyl aminopeptidase
Ligand
BDBM271330
Substrate
n/a
Meas. Tech.
Inhibition of IRAP Assay
IC50
0.770±n/a nM
Citation
 Kawaguchi, K; Ishihata, A; Inagaki, Y; Tsuchiya, K; Hanadate, T; Kanai, A; Kaizawa, H; Kazami, J; Morikawa, H; Hiramoto, M; Enjo, K; Takamatsu, H Pyridine derivative US Patent  US10059720 Publication Date 8/28/2018 
Target
Name:
Leucyl-cystinyl aminopeptidase
Synonyms:
Cystinyl aminopeptidase | GP160 | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | Irap | LCAP_RAT | Leucyl-cystinyl aminopeptidase | Lnpep | Otase | Oxytocinase | P-LAP | Placental leucine aminopeptidase | Vesicle protein of 165 kDa | Vp165
Type:
PROTEIN
Mol. Mass.:
117179.39
Organism:
Rattus norvegicus
Description:
ChEMBL_98523
Residue:
1025
Sequence:
METFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMDEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGTCSVPSARTLVICVFVIVVAVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPIATNGKVFPWAQIRLPTAIIPQRYELSLHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISSVTFMSAVSSQEKQVEILEYPYHEQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAARSAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQDEFSESVKMSTYLVAFIVGEMRNLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKTLDVKKMMKTWTLQKGFPLVTVQRKGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVTDGRNYSEYRSVSLLDKKSDVINLTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNPYVLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLEKLGHMDLSSRLVTRVHKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMATKLFDGWMASNGTQSLPTDVMTTVFKVGARTEKGWLFLFSMYSSMGSEAEKDKILEALASSADAHKLYWLMKSSLDGDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQEFFENQSEATLQLRCVQEAFEVIELNIQWMARNLKTLTLWL
  
Inhibitor
Name:
BDBM271330
Synonyms:
US10059720, Example 145 | US10975091, Example 145
Type:
Small organic molecule
Emp. Form.:
C20H32N2O4S
Mol. Mass.:
396.544
SMILES:
CCCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:7.8,5.5,17.17,wD:7.7,14.13,(-8.67,-2.31,;-7.34,-3.08,;-6,-2.31,;-4.67,-3.08,;-3.33,-2.31,;-2,-3.08,;-2,-4.62,;-.67,-2.31,;.1,-.98,;.67,-3.08,;2,-2.31,;2,-.77,;3.33,,;3.33,1.54,;4.67,2.31,;6,1.54,;7.34,2.31,;7.34,3.85,;8.67,4.62,;6,4.62,;4.67,3.85,;4.67,-.77,;4.67,-2.31,;3.33,-3.08,;-1.44,-.98,;-2.92,-1.37,;-.67,.36,)|
Structure:
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