Reaction Details Report a problem with these data
Target
Serum paraoxonase/arylesterase 1
Ligand
BDBM10860
Substrate
n/a
Meas. Tech.
In Vitro Inhibtion Assay
Ki
340000±0.0 nM
IC50
190000±0.0 nM
Citation
Ekinci, D; Sentürk, M; Beydemir, S; Küfrevioglu, OI; Supuran, CT An alternative purification method for human serum paraoxonase 1 and its interactions with sulfonamides. Chem Biol Drug Des 76:552-8 (2010) [PubMed] Article
More Info.:
Target
Name:
Serum paraoxonase/arylesterase 1
Synonyms:
A-esterase 1 | Aromatic esterase 1 | K-45 | PON | PON 1 | PON1 | PON1_HUMAN | Paraoxonase (PON1) | Paraoxonase (hPON1) | Paraoxonase 1 (PON1) | Serum aryldialkylphosphatase 1 | Serum paraoxonase 1 (PON1)
Type:
Enzyme
Mol. Mass.:
39719.73
Organism:
Homo sapiens (Human)
Description:
P27169
Residue:
355
Sequence:
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL