Reaction Details Report a problem with these data
Target
Serum paraoxonase/arylesterase 1
Ligand
BDBM25902
Substrate
n/a
Meas. Tech.
In Vitro Inhibtion Assay
Ki
702000±0.0 nM
IC50
360000±0.0 nM
Citation
 Ekinci, D; Sentürk, M; Beydemir, S; Küfrevioglu, OI; Supuran, CT An alternative purification method for human serum paraoxonase 1 and its interactions with sulfonamides. Chem Biol Drug Des 76:552-8 (2010) [PubMed]  Article 
Target
Name:
Serum paraoxonase/arylesterase 1
Synonyms:
A-esterase 1 | Aromatic esterase 1 | K-45 | PON | PON 1 | PON1 | PON1_HUMAN | Paraoxonase (PON1) | Paraoxonase (hPON1) | Paraoxonase 1 (PON1) | Serum aryldialkylphosphatase 1 | Serum paraoxonase 1 (PON1)
Type:
Enzyme
Mol. Mass.:
39719.73
Organism:
Homo sapiens (Human)
Description:
P27169
Residue:
355
Sequence:
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
  
Inhibitor
Name:
BDBM25902
Synonyms:
4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid | CHEMBL35 | Frusemide | Furanthril | Furosemide | Furosemide (3) | Furosemide, 4 | Lasix | US10172837, Furosemide
Type:
Small organic molecule
Emp. Form.:
C12H11ClN2O5S
Mol. Mass.:
330.744
SMILES:
NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
Structure:
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