Reaction Details Report a problem with these data
Target
Virion infectivity factor
Ligand
BDBM272225
Substrate
n/a
Meas. Tech.
HIV Integrase Inhibitory Assay
Temperature
298.15±n/a K
IC50
6.40±n/a nM
Comments
extracted
Citation
 Miyazaki, S; Bessho, Y; Adachi, K; Kawashita, S; Isoshima, H; Oshita, K; Fukuda, S Substituted thiazoles as HIV integrase inhibitors US Patent  US10065950 Publication Date 9/4/2018 
Target
Name:
Virion infectivity factor
Synonyms:
HIV integrase | SOR | VIF_HV1N5 | Virion infectivity factor | inhibitory activity | vif
Type:
Enzyme Catalytic Domain
Mol. Mass.:
22719.51
Organism:
Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)
Description:
P12504
Residue:
192
Sequence:
MENRWQVMIVWQVDRMRINTWKRLVKHHMYISRKAKDWFYRHHYESTNPKISSEVHIPLGDAKLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPDLADQLIHLHYFDCFSESAIRNTILGRIVSPRCEYQAGHNKVGSLQYLALAALIKPKQIKPPLPSVRKLTEDRWNKPQKTKGHRGSHTMNGH
  
Inhibitor
Name:
BDBM272225
Synonyms:
US10065950, Example 66
Type:
Small organic molecule
Emp. Form.:
C22H22F2N4O3S
Mol. Mass.:
460.497
SMILES:
CC(C)N1CC(CN)n2cc(-c3ncc(Cc4ccc(F)cc4F)s3)c(=O)c(O)c2C1=O
Structure:
Search PDB for entries with ligand similarity: