Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM82436
Substrate
n/a
Ki
0.72±n/a nM
Comments
PDSP_1024
Citation
 Beauchamp, HT; Chang, RS; Siegl, PK; Gibson, RE In vivo receptor occupancy of the angiotensin II receptor by nonpeptide antagonists: relationship to in vitro affinities and in vivo pharmacologic potency. J Pharmacol Exp Ther 272:612-8 (1995) [PubMed] 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM82436
Synonyms:
1-(2,6-Dichlorophenyl)-4-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-3-propyl-1H-pyrazole-5-carboxylic acid | L-161,274 | L-161274
Type:
Small organic molecule
Emp. Form.:
C27H22Cl2N6O2
Mol. Mass.:
533.409
SMILES:
CCCc1nn(c(C(O)=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)-c1c(Cl)cccc1Cl |(11.96,.91,;10.62,1.68,;9.29,.91,;7.95,1.68,;7.79,3.22,;6.29,3.54,;5.52,2.2,;3.99,2.04,;3.36,.63,;3.08,3.29,;6.55,1.06,;6.23,-.45,;7.37,-1.48,;7.05,-2.98,;8.2,-4.02,;9.66,-3.54,;9.98,-2.03,;8.84,-1,;10.8,-4.57,;12.27,-4.09,;13.41,-5.12,;13.09,-6.63,;11.63,-7.11,;10.48,-6.08,;9.02,-6.55,;7.77,-5.65,;6.53,-6.55,;7,-8.02,;8.54,-8.02,;5.91,5.03,;7.02,6.1,;8.5,5.68,;6.64,7.59,;5.16,8.02,;4.06,6.95,;4.43,5.45,;3.32,4.38,)|
Structure:
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