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TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial
LigandBDBM273168
Substrate/Competitorn/a
Meas. Tech.KAT-II inhibitory assay
pH8±n/a
IC50 15.0±n/a nM
Commentsextracted
Citation Okuyama, MFukunaga, KUsui, KHayashi, NIijima, DHoriuchi, HItagaki, N Bicyclic or tricyclic heterocyclic compound US Patent US10065972 Publication Date 9/4/2018
More Info.:Get all data from this article,  Assay Method
 
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Name:Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:Enzyme
Mol. Mass.:47353.09
Organism:Homo sapiens (Human)
Description:Q8N5Z0
Residue:425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
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BDBM273168
NameBDBM273168
Synonyms:(R)-N-benzyl-1-[7-chloro-6-(2-fluoropropan-2-yl)-4-oxo-4,5-dihydro[1,3]thiazolo[4,5-c]pyridin-2-yl]pyrrolidine-2-carboxamide | US10065972, Example 626
TypeSmall organic molecule
Emp. Form.C21H22ClFN4O2S
Mol. Mass.448.941
SMILESCC(C)(F)c1[nH]c(=O)c2nc(sc2c1Cl)N1CCC[C@@H]1C(=O)NCc1ccccc1 |r|
Structure
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n/a