Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM61018
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
3110±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM61018
Synonyms:
(6Z)-5-azanylidene-6-[[4-[3-(2,6-dimethylphenoxy)propoxy]-3-methoxy-phenyl]methylidene]-[1,3]thiazolo[3,2-a]pyrimidin-7-one | (6Z)-6-[4-[3-(2,6-dimethylphenoxy)propoxy]-3-methoxy-benzylidene]-5-imino-thiazolo[3,2-a]pyrimidin-7-one | (6Z)-6-[[4-[3-(2,6-dimethylphenoxy)propoxy]-3-methoxyphenyl]methylidene]-5-imino-7-thiazolo[3,2-a]pyrimidinone | (6Z)-6-[[4-[3-(2,6-dimethylphenoxy)propoxy]-3-methoxyphenyl]methylidene]-5-imino-[1,3]thiazolo[3,2-a]pyrimidin-7-one | MLS000519246 | SMR000129665 | cid_9550884
Type:
Small organic molecule
Emp. Form.:
C25H25N3O4S
Mol. Mass.:
463.549
SMILES:
COc1cc(\C=C2/C(=O)N=C3SC=CN3C2=N)ccc1OCCCOc1c(C)cccc1C |c:12,t:9|
Structure:
Search PDB for entries with ligand similarity: