Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM80861
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
182±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM80861
Synonyms:
4-[2-(2-Cyclohexyl-5,6-dimethyl-thieno[2,3-d]pyrimidin-4-ylsulfanyl)-acetyl]-3,4-dihydro-1H-quinoxalin-2-one | 4-[2-(2-cyclohexyl-5,6-dimethyl-thieno[2,3-d]pyrimidin-4-yl)sulfanylethanoyl]-1,3-dihydroquinoxalin-2-one | 4-[2-(2-cyclohexyl-5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetyl]-1,3-dihydroquinoxalin-2-one | 4-[2-[(2-cyclohexyl-5,6-dimethyl-4-thieno[2,3-d]pyrimidinyl)thio]-1-oxoethyl]-1,3-dihydroquinoxalin-2-one | 4-[2-[(2-cyclohexyl-5,6-dimethyl-thieno[2,3-d]pyrimidin-4-yl)thio]acetyl]-1,3-dihydroquinoxalin-2-one | MLS000555707 | SMR000173088 | cid_3203918
Type:
Small organic molecule
Emp. Form.:
C24H26N4O2S2
Mol. Mass.:
466.619
SMILES:
Cc1sc2nc(nc(SCC(=O)N3CC(=O)Nc4ccccc34)c2c1C)C1CCCCC1
Structure:
Search PDB for entries with ligand similarity: