Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM80874
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
4750±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM80874
Synonyms:
1-[2-(4-tert-butylphenoxy)ethyl]-7-methyl-1H-indole-2,3-dione | 1-[2-(4-tert-butylphenoxy)ethyl]-7-methyl-indole-2,3-dione | 1-[2-(4-tert-butylphenoxy)ethyl]-7-methyl-isatin | 1-[2-(4-tert-butylphenoxy)ethyl]-7-methylindole-2,3-dione | MLS000580079 | SMR000199323 | cid_2200159
Type:
Small organic molecule
Emp. Form.:
C21H23NO3
Mol. Mass.:
337.4122
SMILES:
Cc1cccc2C(=O)C(=O)N(CCOc3ccc(cc3)C(C)(C)C)c12
Structure:
Search PDB for entries with ligand similarity: