Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM49608
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
17100±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM49608
Synonyms:
3-(4-Biphenyl-4-yl-thiazol-2-ylamino)-6,7-dimethoxy-3H-isobenzofuran-1-one | 6,7-dimethoxy-3-[[4-(4-phenylphenyl)-1,3-thiazol-2-yl]amino]-3H-2-benzofuran-1-one | 6,7-dimethoxy-3-[[4-(4-phenylphenyl)-2-thiazolyl]amino]-3H-isobenzofuran-1-one | 6,7-dimethoxy-3-[[4-(4-phenylphenyl)thiazol-2-yl]amino]phthalide | MLS000588041 | SMR000220040 | cid_3792553
Type:
Small organic molecule
Emp. Form.:
C25H20N2O4S
Mol. Mass.:
444.502
SMILES:
COc1ccc2C(Nc3nc(cs3)-c3ccc(cc3)-c3ccccc3)OC(=O)c2c1OC
Structure:
Search PDB for entries with ligand similarity: