Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM80943
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
5250±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM80943
Synonyms:
2-[6-[(5E)-2-keto-5-p-anisylidene-4-thioxo-thiazolidin-3-yl]hexanoylamino]benzoic acid | 2-[6-[(5E)-5-[(4-methoxyphenyl)methylidene]-2-oxidanylidene-4-sulfanylidene-1,3-thiazolidin-3-yl]hexanoylamino]benzoic acid | 2-[6-[(5E)-5-[(4-methoxyphenyl)methylidene]-2-oxo-4-sulfanylidene-1,3-thiazolidin-3-yl]hexanoylamino]benzoic acid | 2-[[6-[(5E)-5-[(4-methoxyphenyl)methylidene]-2-oxo-4-sulfanylidene-3-thiazolidinyl]-1-oxohexyl]amino]benzoic acid | MLS000680173 | SMR000324433 | cid_16195668
Type:
Small organic molecule
Emp. Form.:
C24H24N2O5S2
Mol. Mass.:
484.588
SMILES:
COc1ccc(\C=C2\SC(=O)N(CCCCCC(=O)Nc3ccccc3C(O)=O)C2=S)cc1
Structure:
Search PDB for entries with ligand similarity: