Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM52143
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
4640±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM52143
Synonyms:
2-cyano-N-(phenylmethyl)-2-(3-pyrrolidin-1-ylquinoxalin-2-yl)ethanamide | 2-cyano-N-(phenylmethyl)-2-[3-(1-pyrrolidinyl)-2-quinoxalinyl]acetamide | MLS000057770 | N-benzyl-2-cyano-2-(3-pyrrolidin-1-ylquinoxalin-2-yl)acetamide | N-benzyl-2-cyano-2-(3-pyrrolidinoquinoxalin-2-yl)acetamide | SMR000061926 | cid_2998487
Type:
Small organic molecule
Emp. Form.:
C22H21N5O
Mol. Mass.:
371.435
SMILES:
O=C(NCc1ccccc1)C(C#N)c1nc2ccccc2nc1N1CCCC1
Structure:
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