Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM42925
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM42925
Synonyms:
(2E)-2-(3-methyl-1H-benzimidazol-2-ylidene)-4-(2-naphthalenyloxy)-3-oxobutanenitrile | (2E)-2-(3-methyl-1H-benzimidazol-2-ylidene)-4-naphthalen-2-yloxy-3-oxidanylidene-butanenitrile | (2E)-2-(3-methyl-1H-benzimidazol-2-ylidene)-4-naphthalen-2-yloxy-3-oxobutanenitrile | (2E)-3-keto-2-(3-methyl-1H-benzimidazol-2-ylidene)-4-(2-naphthoxy)butyronitrile | MLS000055275 | SMR000061763 | cid_5742548
Type:
Small organic molecule
Emp. Form.:
C22H17N3O2
Mol. Mass.:
355.3893
SMILES:
Cn1c(nc2ccccc12)C(C#N)C(=O)COc1ccc2ccccc2c1
Structure:
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