Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83550
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
8430±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83550
Synonyms:
MLS000553953 | N-(4-Methoxy-benzylidene)-N'-[2-(4-methyl-piperazine-1-sulfonyl)-4-nitro-phenyl]-hydrazine | N-[(4-methoxyphenyl)methylideneamino]-2-(4-methylpiperazin-1-yl)sulfonyl-4-nitro-aniline | N-[(4-methoxyphenyl)methylideneamino]-2-(4-methylpiperazin-1-yl)sulfonyl-4-nitroaniline | N-[(4-methoxyphenyl)methylideneamino]-2-[(4-methyl-1-piperazinyl)sulfonyl]-4-nitroaniline | SMR000171842 | [2-(4-methylpiperazino)sulfonyl-4-nitro-phenyl]-(p-anisylideneamino)amine | cid_3127058
Type:
Small organic molecule
Emp. Form.:
C19H23N5O5S
Mol. Mass.:
433.481
SMILES:
COc1ccc(CN=Nc2ccc(cc2S(=O)(=O)N2CCN(C)CC2)[N+]([O-])=O)cc1 |w:8.8|
Structure:
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