Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83652
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
4480±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83652
Synonyms:
9H-fluorene-2,7-disulfonohydrazide | MLS001196340 | SMR000556375 | cid_2136107
Type:
Small organic molecule
Emp. Form.:
C13H14N4O4S2
Mol. Mass.:
354.405
SMILES:
NNS(=O)(=O)c1ccc-2c(Cc3cc(ccc-23)S(=O)(=O)NN)c1
Structure:
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