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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM61554
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59650±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM61554
Synonyms:
5-Acetoxy-6-bromo-2-carbamimidoylsulfanylmethyl-1-phenyl-1H-indole-3-carboxylic acid ethyl ester | 5-acetoxy-2-[(amidinothio)methyl]-6-bromo-1-phenyl-indole-3-carboxylic acid ethyl ester | 5-acetyloxy-6-bromo-2-[(carbamimidoylthio)methyl]-1-phenyl-3-indolecarboxylic acid ethyl ester | MLS001029481 | SMR000425510 | cid_3352410 | ethyl 5-acetyloxy-6-bromanyl-2-(carbamimidoylsulfanylmethyl)-1-phenyl-indole-3-carboxylate | ethyl 5-acetyloxy-6-bromo-2-(carbamimidoylsulfanylmethyl)-1-phenylindole-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C21H20BrN3O4S
Mol. Mass.:
490.37
SMILES:
CCOC(=O)c1c(CSC(N)=N)n(-c2ccccc2)c2cc(Br)c(OC(C)=O)cc12
Structure:
Search PDB for entries with ligand similarity: