Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCyclin-dependent kinase 2
LigandBDBM84544
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH8±0
Temperature295.15±0 K
IC50 8e+1± 0 nM
Citation Jautelat, RBrumby, TSchäfer, MBriem, HEisenbrand, GSchwahn, SKrüger, MLücking, UPrien, OSiemeister, G From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors. Chembiochem6:531-40 (2005) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cyclin-dependent kinase 2
Name:CDK2/Bovine cyclin A
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM84544
NameBDBM84544
Synonyms:Indirubin derivative, 36 (X=NO)
TypeSmall organic molecule
Emp. Form.C26H30N4O10S
Mol. Mass.590.602
SMILESCN(C)S(=O)(=O)c1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\OCCO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a