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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50005265
Substrate
n/a
Ki
7267±n/a nM
Comments
PDSP_722
Citation
 Pauwels, PJ; Van Gompel, P; Leysen, JE Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1A receptors that are negatively coupled to adenylate cyclase in permanently transfected HeLa cells. Biochem Pharmacol 45:375-83 (1993) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50005265
Synonyms:
(+/-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine | (-)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine | (Rec)2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine; compound with 2-(2,5-dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine | 2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine | 2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine((R)-(-)-DOM) | 2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine(DOM) | CHEMBL8600 | DOM | DOM,R(-) | Racemic DOM
Type:
Small organic molecule
Emp. Form.:
C12H19NO2
Mol. Mass.:
209.2848
SMILES:
COc1cc(CC(C)N)c(OC)cc1C
Structure:
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