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TargetNa/K-ATPase
LigandBDBM50000259
Substrate/Competitorn/a
Meas. Tech.ChEBML_76079
IC50 2000±n/a nM
Citation Weidmann, KHerling, AWLang, HJScheunemann, KHRippel, RNimmesgern, HScholl, TBickel, MMetzger, H 2-[(2-pyridylmethyl)sulfinyl]-1H-thieno[3,4-d]imidazoles. A novel class of gastric H+/K(+)-ATPase inhibitors. J Med Chem35:438-50 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Na/K-ATPase
Name:Potassium-transporting ATPase
Synonyms:Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1
Type:Enzyme
Mol. Mass.:114279.23
Organism:Sus scrofa (Pig)
Description:P19156
Residue:1034
Sequence:
MGKAENYELYQVELGPGPSGDMAAKMSKKKAGRGGGKRKEKLENMKKEMEINDHQLSVAE
LEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAI
CLIAFAIQASEGDLTTDDNLYLALALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQAT
VIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILQAQGRKVDNSSLTGESEPQTRSPE
CTHESPLETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEH
FVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKR
LASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHSADTTEDQSGQT
FDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGY
RERFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHVLVMKGAPERVLERCSSILIKGQELPL
DEQWREAFQTAYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLSFAGLVS
MIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRV
PVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGA
IVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFD
NLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESD
IMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRPQW
ENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFF
RNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGV
RCCPGSWWDQELYY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50000259
NameBDBM50000259
Synonyms:2-[4-(2,2,3,3,4,4,5,5-Octafluoro-pentyloxy)-pyridin-2-ylmethanesulfinyl]-3H-thieno[3,4-d]imidazole | CHEMBL140688
TypeSmall organic molecule
Emp. Form.C16H11F8N3O2S2
Mol. Mass.493.395
SMILESFC(F)C(F)(F)C(F)(F)C(F)(F)COc1ccnc(CS(=O)c2nc3cscc3[nH]2)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a