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Target
Kappa-type opioid receptor
Ligand
BDBM50000268
Substrate
n/a
Meas. Tech.
ChEMBL_220946 (CHEMBL824621)
IC50
250±n/a nM
Citation
 Scopes, DI; Hayes, NF; Bays, DE; Belton, D; Brain, J; Brown, DS; Judd, DB; McElroy, AB; Meerholz, CA; Naylor, A New kappa-receptor agonists based upon a 2-[(alkylamino)methyl]piperidine nucleus. J Med Chem 35:490-501 (1992) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50000268
Synonyms:
1-[2-(3,4-Dichloro-phenyl)-acetyl]-2-pyrrolidin-1-ylmethyl-piperidine-4-carboxylic acid methyl ester | CHEMBL359252
Type:
Small organic molecule
Emp. Form.:
C20H26Cl2N2O3
Mol. Mass.:
413.338
SMILES:
COC(=O)[C@@H]1CCN([C@H](CN2CCCC2)C1)C(=O)Cc1ccc(Cl)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: