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Target
Kappa-type opioid receptor
Ligand
BDBM50000292
Substrate
n/a
Meas. Tech.
ChEMBL_145685 (CHEMBL753311)
IC50
3.5±n/a nM
Citation
 Scopes, DI; Hayes, NF; Bays, DE; Belton, D; Brain, J; Brown, DS; Judd, DB; McElroy, AB; Meerholz, CA; Naylor, A New kappa-receptor agonists based upon a 2-[(alkylamino)methyl]piperidine nucleus. J Med Chem 35:490-501 (1992) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50000292
Synonyms:
2-(3,4-Dichloro-phenyl)-1-[2-(2,5-dihydro-pyrrol-1-ylmethyl)-piperidin-1-yl]-ethanone | CHEMBL343246
Type:
Small organic molecule
Emp. Form.:
C18H22Cl2N2O
Mol. Mass.:
353.286
SMILES:
Clc1ccc(CC(=O)N2CCCCC2CN2CC=CC2)cc1Cl |c:18|
Structure:
Search PDB for entries with ligand similarity: