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Target
Prolyl 4-hydroxylase subunit alpha-1
Ligand
BDBM26106
Substrate
n/a
Meas. Tech.
ChEMBL_157457 (CHEMBL765597)
IC50
2890±n/a nM
Citation
 Cunliffe, CJ; Franklin, TJ; Hales, NJ; Hill, GB Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives. J Med Chem 35:2652-8 (1992) [PubMed]  Article 
Target
Name:
Prolyl 4-hydroxylase subunit alpha-1
Synonyms:
P4HA1_RAT | P4ha | P4ha1 | Prolyl 4-hydroxylase alpha-1 subunit
Type:
PROTEIN
Mol. Mass.:
60891.28
Organism:
Rattus norvegicus
Description:
ChEMBL_157460
Residue:
534
Sequence:
MIWGVLMMGILLPQCSAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKDMSDGFISNLTIQRQYFPNDEDQVGAAKALFRLQDTYNLDTNTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALMQLEEGEMSTVDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIMSKEKDANKSASGDQSDQKTTPKKKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYRVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
  
Inhibitor
Name:
BDBM26106
Synonyms:
CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylglycine | [(carboxymethyl)carbamoyl]formic acid
Type:
Small organic molecule
Emp. Form.:
C4H5NO5
Mol. Mass.:
147.0862
SMILES:
OC(=O)CNC(=O)C(O)=O
Structure:
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