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Target
Estrogen receptor
Ligand
BDBM20608
Substrate
n/a
Meas. Tech.
ChEMBL_1668112 (CHEMBL4018000)
IC50
33±n/a nM
Citation
 Misawa, T; Tanaka, K; Demizu, Y; Kurihara, M Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic. Bioorg Med Chem Lett 27:2590-2593 (2017) [PubMed]  Article 
Target
Name:
Estrogen receptor
Synonyms:
ESR1_MOUSE | Esr | Esr1 | Estr | Estra | Estrogen receptor alpha | Nr3a1
Type:
PROTEIN
Mol. Mass.:
66969.87
Organism:
Mus musculus
Description:
ChEMBL_648798
Residue:
599
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPTVFNYPEGAAYEFNAAAAAAAAASAPVYGQSGIAYGPGSEAAAFSANSLGAFPQLNSVSPSPLMLLHPPPQLSPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSNEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGASGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPEEPSQTQLATTSSTSAHSLQTYYIPPEAEGFPNTI
  
Inhibitor
Name:
BDBM20608
Synonyms:
4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol | AFIMOXIFENE | CHEMBL489 | [3H]4-OHT | cid_449459
Type:
Small organic molecule
Emp. Form.:
C26H29NO2
Mol. Mass.:
387.514
SMILES:
CC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Structure:
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