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TargetDopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
LigandBDBM50002159
Substrate/Competitorn/a
Meas. Tech.ChEMBL_58698
IC50 100±n/a nM
Citation Böttcher, HBarnickel, GHausberg, HHHaase, AFSeyfried, CAEiermann, V Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-1-pyridylalkyl)indoles. A novel conformational model to explain structure-activity relationships. J Med Chem35:4020-6 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
Name:Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
Synonyms:DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DOPAMINE D2/D4 | DRD2 | Dopamine D2 receptor | Dopamine2-like
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:50931.60
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat striatal membranes.
Residue:444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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BDBM50002159
NameBDBM50002159
Synonyms:1-Methyl-3-[4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]-1H-indole | CHEMBL131356
TypeSmall organic molecule
Emp. Form.C24H28N2
Mol. Mass.344.4925
SMILESCn1cc(CCCCN2CCC(=CC2)c2ccccc2)c2ccccc12 |c:11|
Structure
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n/a