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Target
Prostacyclin receptor
Ligand
BDBM50002404
Substrate
n/a
Meas. Tech.
ChEBML_158010
IC50
160±n/a nM
Citation
 Meanwell, NA; Rosenfeld, MJ; Wright, JJ; Brassard, CL; Buchanan, JO; Federici, ME; Fleming, JS; Seiler, SM Structure-activity relationships associated with 3,4,5-triphenyl-1H-pyrazole-1-nonanoic acid, a nonprostanoid prostacyclin mimetic. J Med Chem 35:389-97 (1992) [PubMed]  Article 
Target
Name:
Prostacyclin receptor
Synonyms:
PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40968.22
Organism:
Homo sapiens (Human)
Description:
The membranes prepared from human platelet were used in binding assay.
Residue:
386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
  
Inhibitor
Name:
BDBM50002404
Synonyms:
9-(3,4,5-Triphenyl-pyrazol-1-yl)-nonanoic acid | CHEMBL118567
Type:
Small organic molecule
Emp. Form.:
C30H32N2O2
Mol. Mass.:
452.5873
SMILES:
OC(=O)CCCCCCCCn1nc(c(c1-c1ccccc1)-c1ccccc1)-c1ccccc1
Structure:
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