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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50246724
Substrate
n/a
Meas. Tech.
ChEMBL_1676736 (CHEMBL4026879)
Ki
4400±n/a nM
Citation
 Fish, I; Stößel, A; Eitel, K; Valant, C; Albold, S; Huebner, H; Möller, D; Clark, MJ; Sunahara, RK; Christopoulos, A; Shoichet, BK; Gmeiner, P Structure-Based Design and Discovery of New M J Med Chem 60:9239-9250 (2017) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50246724
Synonyms:
CHEMBL4085451
Type:
Small organic molecule
Emp. Form.:
C14H22INO
Mol. Mass.:
347.2351
SMILES:
[I-].COc1cccc2CC(CCc12)[N+](C)(C)C
Structure:
Search PDB for entries with ligand similarity: