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Target
Dihydrofolate reductase
Ligand
BDBM50003057
Substrate
n/a
Meas. Tech.
ChEMBL_54094 (CHEMBL668425)
IC50
>95000±n/a nM
Citation
 Gangjee, A; Patel, J; Kisliuk, RL; Gaumont, Y 5,10-Methylenetetrahydro-5-deazafolic acid and analogues: synthesis and biological activities. J Med Chem 35:3678-85 (1992) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50003057
Synonyms:
7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraaza-cyclopenta[a]naphthalen-9-one | CHEMBL122959
Type:
Small organic molecule
Emp. Form.:
C12H13N5O
Mol. Mass.:
243.2645
SMILES:
Cc1n(C)c(C)c2c1cnc1nc(N)[nH]c(=O)c21
Structure:
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