Reaction Details Report a problem with these data
Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50003201
Substrate
n/a
Meas. Tech.
ChEBML_47804
IC50
0.910000±n/a nM
Citation
 Tilley, JW; Danho, W; Shiuey, SJ; Kulesha, I; Swistok, J; Makofske, R; Michalewsky, J; Triscari, J; Nelson, D; Weatherford, S Analogs of Ac-CCK-7 incorporating dipeptide mimics in place of Met28-Gly29. J Med Chem 35:3774-83 (1992) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCKBR | Cholecystokinin B receptor | GASR_BOVIN
Type:
PROTEIN
Mol. Mass.:
48807.54
Organism:
Bos taurus
Description:
ChEMBL_48437
Residue:
454
Sequence:
MELLKPNRSVLGSGPGPGASLCRSGGPLLNGSGTGNLSCEPPRIRGAGTRELELAIRVTLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVVCKAVSYFMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWMLSGLLMVPYPVYTAVQPAGPRVLQCMHRWPSARVRQTWSVLLLLLLFFVPGVVMAVAYGLISRELYLGLRFDGDSDSESQSRVGSQGGLPGGTGQGPAQANGRCRSETRLAGEDGDGCYVQLPRSRPALEMSALTAPTPGPGSGTRPAQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLTYASACVNPLVYCFMHRRFRQACLDTCTRCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50003201
Synonyms:
CHEMBL386376 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{2-[2-{3-[2-carboxyamino-3-(4-sulfo-phenyl)-propionylamino]-2-methyl-benzoylamino}-3-(1H-indol-3-yl)-propionylamino]-4-methylsulfanyl-butyrylamino}-succinamic acid
Type:
Small organic molecule
Emp. Form.:
C47H52N8O13S2
Mol. Mass.:
1001.092
SMILES:
CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(cc2)S(O)(=O)=O)NC(O)=O)c1C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Structure:
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