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Target
Catechol O-methyltransferase
Ligand
BDBM50004045
Substrate
n/a
Meas. Tech.
ChEMBL_47058 (CHEMBL661099)
IC50
1500±n/a nM
Citation
 Pérez, RA; Fernández-Alvarez, E; Nieto, O; Piedrafita, FJ Dihydroxynitrobenzaldehydes and hydroxymethoxynitrobenzaldehydes: synthesis and biological activity as catechol-O-methyltransferase inhibitors. J Med Chem 35:4584-8 (1993) [PubMed]  Article 
Target
Name:
Catechol O-methyltransferase
Synonyms:
COMT | COMT_PIG
Type:
PROTEIN
Mol. Mass.:
20586.58
Organism:
Sus scrofa
Description:
ChEMBL_105412
Residue:
186
Sequence:
KERAMHVGRKKGQIVDTVVQEQRPSVLLELGAYCGYSAVRMARLLLPSARLLTIELNPDNAAIAQQVVDFAGLQDRVTVVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGCGRFECTHFSSYLEYSQMVDGLEKAVYKGPGSPAQP
  
Inhibitor
Name:
BDBM50004045
Synonyms:
2,3-Dihydroxy-4-nitro-benzaldehyde | CHEMBL357072
Type:
Small organic molecule
Emp. Form.:
C7H5NO5
Mol. Mass.:
183.1183
SMILES:
Oc1c(O)c(ccc1C=O)[N+]([O-])=O
Structure:
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