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Target
cGMP-dependent 3',5'-cyclic phosphodiesterase
Ligand
BDBM107767
Substrate
n/a
Meas. Tech.
ChEMBL_1677919 (CHEMBL4028062)
Ki
4.2±n/a nM
Citation
 Helal, CJ; Arnold, E; Boyden, T; Chang, C; Chappie, TA; Fisher, E; Hajos, M; Harms, JF; Hoffman, WE; Humphrey, JM; Pandit, J; Kang, Z; Kleiman, RJ; Kormos, BL; Lee, CW; Lu, J; Maklad, N; McDowell, L; McGinnis, D; O'Connor, RE; O'Donnell, CJ; Ogden, A; Piotrowski, M; Schmidt, CJ; Seymour, PA; Ueno, H; Vansell, N; Verhoest, PR; Yang, EX Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate. J Med Chem 61:1001-1018 (2018) [PubMed]  Article 
Target
Name:
cGMP-dependent 3',5'-cyclic phosphodiesterase
Synonyms:
PDE2A_RAT | Pde2a | Phosphodiesterase 2A
Type:
PROTEIN
Mol. Mass.:
104640.72
Organism:
Rattus norvegicus
Description:
ChEMBL_156330
Residue:
928
Sequence:
MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPQPCADSLQDALLSLGAVIDIAGLRQAAKDALSAVLPKVETVYTYLVDGESRLVCEDPPHELPQEGKIREAVISRKRLSCDGLGPSDLLGKPLARLVAPLAPDTQVLVIPLLDKETGTVAAVILVHCGQLSDSEEQSLQVVEKHALVALQRVQALQQRRPEAVQNTSADPSEDQKDEKGYTAHDRKILQLCGELYDLDATSLQLKVLRYLQQETQATHCCLLLVSEDNLQLSCKVIGEKVLGEEVSFPLTMGRLGQVVEDKQCIQLKDLTSDDVQQLQNMLGCELRAMLCVPVISRATDQVVALACAFNKLGGDFFTDEDERAIQHCFHYTGTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFANFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELSNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDVTRAPVNGCCSLEG
  
Inhibitor
Name:
BDBM107767
Synonyms:
US11419874, PF-05180999 | US8598155, 2
Type:
Small organic molecule
Emp. Form.:
C19H17F3N8
Mol. Mass.:
414.3871
SMILES:
Cc1nc(-c2cnn(C)c2-c2ccc(cn2)C(F)(F)F)c2c(ncnn12)N1CCC1
Structure:
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