Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50005305
Substrate
n/a
Meas. Tech.
ChEBML_195740
IC50
8±n/a nM
Citation
Ocain, TD; Deininger, DD; Russo, R; Senko, NA; Katz, A; Kitzen, JM; Mitchell, R; Oshiro, G; Russo, A; Stupienski, R New modified heterocyclic phenylalanine derivatives. Incorporation into potent inhibitors of human renin. J Med Chem 35:823-32 (1992) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50005305
Synonyms:
(SCRIP)3-[2-(2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-4-cyclohexyl-2-hydroxy-butyric acid methyl ester | CHEMBL352523
Type:
Small organic molecule
Emp. Form.:
C31H49N3O7
Mol. Mass.:
575.7367
SMILES:
COC(=O)C(O)[C@H](CC1CCCCC1)NC(=O)C(CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C