Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor
Ligand
BDBM50005849
Substrate
n/a
Meas. Tech.
ChEMBL_138319 (CHEMBL748199)
Ki
86000±n/a nM
Citation
 Nordvall, G; Sundquist, S; Glas, G; Gogoll, A; Nilvebrant, L; Hacksell, U Analogues of the muscarinic agent 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]: synthesis and pharmacology. J Med Chem 35:1541-50 (1992) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor
Synonyms:
GPM3 | Muscarinic acetylcholine receptor M3
Type:
n/a
Mol. Mass.:
66272.13
Organism:
Cavia porcellus
Description:
n/a
Residue:
587
Sequence:
MTLHSNSTTLPLFPNISTSWIHSPSEAGLPPGTVTHFGSYNISQAAGNFSSLNGTTSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVSFKVNKQLKHVNNYFLLSLADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSLKHSSRRKYSRCHFWFATKSWKPNAGQMDQDHSSSDSWNNYDAAASLENSASDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEDLEPMDMERNASKPQTQKSMDDGGSFQKSFSNLPIQLESTMDTAKTSDANSSVSKTMATLPLSFKEATLAKRFALRTRSQITKRKRMSLIKEKRAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRNTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
  
Inhibitor
Name:
BDBM50005849
Synonyms:
CHEMBL290715 | spiro[4-azabicyclo[2.2.2]octane-2,4'-[1,3]dioxolane]
Type:
Small organic molecule
Emp. Form.:
C9H15NO2
Mol. Mass.:
169.2209
SMILES:
C1OCC2(CN3CCC2CC3)O1 |(15.01,-.56,;15.79,-1.89,;14.76,-3.03,;13.35,-2.41,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,;13.51,-.88,)|
Structure:
Search PDB for entries with ligand similarity: