Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50006123
Substrate
n/a
Meas. Tech.
ChEMBL_195925 (CHEMBL803394)
pH
7.4±n/a
IC50
810±n/a nM
Comments
extracted
Citation
Martin, SF; Austin, RE; Oalmann, CJ; Baker, WR; Condon, SL; deLara, E; Rosenberg, SH; Spina, KP; Stein, HH; Cohen, J 1,2,3-trisubstituted cyclopropanes as conformationally restricted peptide isosteres: application to the design and synthesis of novel renin inhibitors. J Med Chem 35:1710-21 (1992) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50006123
Synonyms:
2,3-Diphenyl-cyclopropanecarboxylic acid [1-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-thiazol-4-yl-ethyl]-amide | CHEMBL296051
Type:
Small organic molecule
Emp. Form.:
C36H47N3O4S
Mol. Mass.:
617.841
SMILES:
CC(C)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cscn1)NC(=O)C1[C@@H]([C@@H]1c1ccccc1)c1ccccc1