Reaction Details Report a problem with these data
Target
Cholesterol side-chain cleavage enzyme, mitochondrial
Ligand
BDBM50006551
Substrate
n/a
Meas. Tech.
ChEMBL_53758 (CHEMBL662006)
IC50
67000±n/a nM
Citation
 Hartmann, RW; Batzl, C; Pongratz, TM; Mannschreck, A Synthesis and aromatase inhibition of 3-cycloalkyl-substituted 3-(4-aminophenyl)piperidine-2,6-diones. J Med Chem 35:2210-4 (1992) [PubMed]  Article 
Target
Name:
Cholesterol side-chain cleavage enzyme, mitochondrial
Synonyms:
CP11A_BOVIN | CYP11A1 | CYPXIA1 | Cholesterol desmolase | Cholesterol side-chain cleavage enzyme, mitochondrial | Cytochrome P450 11A1 | Cytochrome P450 11A1 (CYP11A1) | P450(scc)
Type:
Protein
Mol. Mass.:
60346.75
Organism:
Bos taurus (Bovine)
Description:
P00189
Residue:
520
Sequence:
MLARGLPLRSALVKACPPILSTVGEGWGHHRVGTGEGAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQA
  
Inhibitor
Name:
BDBM50006551
Synonyms:
(+)3-(4-Amino-phenyl)-3-cyclohexyl-piperidine-2,6-dione | (-)3-(4-Amino-phenyl)-3-cyclohexyl-piperidine-2,6-dione | 3-(4-Amino-phenyl)-3-cyclohexyl-piperidine-2,6-dione | CHEMBL70901
Type:
Small organic molecule
Emp. Form.:
C17H22N2O2
Mol. Mass.:
286.3688
SMILES:
Nc1ccc(cc1)C1(CCC(=O)NC1=O)C1CCCCC1
Structure:
Search PDB for entries with ligand similarity: