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TargetMuscarinic acetylcholine receptor M1
LigandBDBM50003369
Substrate/Competitorn/a
Meas. Tech.ChEMBL_138797
IC50 18±n/a nM
Citation Sauerberg, POlesen, PHNielsen, STreppendahl, SSheardown, MJHonoré, TMitch, CHWard, JSPike, AJBymaster, FP Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines . J Med Chem35:2274-83 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M1
Name:Muscarinic receptor M1 and M2
Synonyms:Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:Enzyme Catalytic Domain
Mol. Mass.:51390.46
Organism:RAT
Description:Cholinergic, muscarinic M1 CHRM1 RAT::P08482
Residue:460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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BDBM50003369
NameBDBM50003369
Synonyms:1-Methyl-5-(4-propoxy-[1,2,5]thiadiazol-3-yl)-1,2,3,6-tetrahydro-pyridine | 1-Methyl-5-(4-propoxy-[1,2,5]thiadiazol-3-yl)-1,2,3,6-tetrahydro-pyridine; oxalic acid | 1-methyl-5-(4-propoxy-1,2,5-thiadiazol-3-yl)-1,2,3,6-tetrahydropyridine | CHEMBL303922 | CHEMBL308803
TypeSmall organic molecule
Emp. Form.C11H17N3OS
Mol. Mass.239.337
SMILESCCCOc1nsnc1C1=CCCN(C)C1 |t:10|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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